Customize Consent Preferences

We use cookies to help you navigate efficiently and perform certain functions. You will find detailed information about all cookies under each consent category below.

The cookies that are categorised as "Necessary" are stored on your browser as they are essential for enabling the basic functionalities of the site. ... 

Always Active

Necessary cookies are required to enable the basic features of this site, such as providing secure log-in or adjusting your consent preferences. These cookies do not store any personally identifiable data.

No cookies to display.

Functional cookies help perform certain functionalities like sharing the content of the website on social media platforms, collecting feedback, and other third-party features.

No cookies to display.

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics such as the number of visitors, bounce rate, traffic source, etc.

No cookies to display.

Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.

No cookies to display.

Advertisement cookies are used to provide visitors with customised advertisements based on the pages you visited previously and to analyze the effectiveness of the ad campaigns.

No cookies to display.

« Back to Glossary Index

Signs and Symptoms of Orofacial Granulomatosis:
- Persistent or recurrent enlargement of the lips, causing them to protrude
- Midline fissuring of the lip (median cheilitis) or angular cheilitis (sores at the corner of the mouth)
- Oral ulceration (mouth ulcers) which may be aphthous-like or chronic and deep
- Full width gingivitis
- Fissured tongue

Causes and Associations of Orofacial Granulomatosis:
- Unknown cause
- Non-caseating granulomatous inflammation
- Disagreement on whether it represents an early form of Crohn's disease or sarcoidosis
- Possible association with oral Crohn's disease
- Suspected sources of antigens include metals and additives/preservatives in foods

Diagnosis of Orofacial Granulomatosis:
- Usually diagnosed through tissue biopsy
- Cannot reliably distinguish between OFG, Crohn's disease, or sarcoidosis
- Other causes of granulomatous inflammation are ruled out

Classification of Orofacial Granulomatosis:
- OFG could be classified as a type of cheilitis and a granulomatous condition

Treatment of Orofacial Granulomatosis:
- Anti-tumor necrosis factor α drugs (e.g. infliximab)
- Dietary restriction of suspected or proven antigens
- Management may involve cinnamon or benzoate-free diets

« Back to Glossary Index
chevron-down linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram