Early History and Establishment of the Society
- The idea of the Angle School of Orthodontia originated during a meeting of the National Dental Association in 1899.
- Dr. Edward Hartley Angle had been teaching orthodontia at four different colleges.
- Unable to convince dental colleges to have a separate Department in Orthodontics, Angle was approached by four individuals to teach them orthodontics in St. Louis in 1900.
- The course was repeated in 1900 with additional students, establishing the first school of orthodontics.
- In 1900, the class organised a society known as The Society of Orthodontists, which later became the American Association of Orthodontists.
- Dr. Anna Hopkins, Angle's longtime secretary, became the first secretary of the Society.
- The Society played a significant role in the development of orthodontics.

Relocation and Expansion
- In 1907, the school moved from St. Louis to New York City.
- Only one class graduated in New York before the school relocated again.
- In 1908, the school moved to New London, Connecticut.
- Classes were initially held at Munsey Building and later at the Harbor School.
- In 1918, Angle purchased a Craftsman home in Pasadena, California, where the school was eventually moved.

Angle College of Orthodontia
- Classes resumed in Pasadena in 1920.
- Notable orthodontists such as Cecil C. Steiner, Spencer Atkinson, and George W. Hahn graduated from this class.
- Dr. Anna Hopkins, known as Mother Angle, played a significant role in teaching at the school.
- In 1922, the Angle Society of Orthodontics was established by the students.
- The school received a charter from the State of California in 1924 and became Angle College of Orthodontia.

Notable Graduates
- Albert Ketcham, Alfred Paul Rogers, Albin Oppenheim, Allan G. Brodie, Arthur Roberts.
- Bernhard Weinberger, B. Frank Gray, Cecil C. Steiner, Charles A. Hawley, Charles H. Tweed.
- Charles Blackmar, Charles Boyd, Copeland Shelden, Dean Harold Noyes, Ernest Martin Setzer.
- F. Ishii, F. W. Rafter, Frederick C. Kemple, Frank A. Gough, Frank E. Shelden.
- Frank M. Casto, Frederick Bogue Noyes, Frederick Lester Stanton, Genette Weaverling Harbour, George W. Hahn.

Miscellaneous
- Dr. Anna Hopkins married Edward Hartley Angle in 1906 and became Mrs. Edward Hartley Angle.
- The school moved to Pasadena, California in 1918.
- The school's charter was received from the State of California in 1924.