Uses and Applications of Chlorhexidine
– Disinfectant and antiseptic
– Skin disinfection before surgery
– Sterilization of surgical instruments
– Cleaning wounds
– Prevention of dental plaque
– Topical use for surgical scrubs, skin wounds, and preoperative skin preparation
– Dental use for reducing plaque build-up and improving mild gingivitis
– Veterinary uses for topical disinfection of wounds and managing skin infections in animals
– Use in the dairy farming industry
– Use as eye drops for Acanthamoeba keratitis
– Reduction of incidence of omphalitis and neonatal mortality
– Use as a disinfectant in industrial settings
– Use as an ingredient in dental products

Antiseptic Properties of Chlorhexidine
– Active against Gram-positive and Gram-negative organisms
– Effective against facultative anaerobes, aerobes, and yeasts
– Particularly effective against Gram-positive bacteria
– Ineffective against polioviruses and adenoviruses
– More effective than povidone-iodine for clean surgery

Side Effects and Precautions of Chlorhexidine
– Ototoxicity if put into a ruptured eardrum
– Does not meet European specifications for hand disinfectant
– Daily bathing with chlorhexidine reduces the risk of hospital-acquired infections
– Prolonged use may have carcinogenic potential
– Stomach irritation or nausea if ingested, high concentration can be fatal if aspirated into lungs
– Corneal damage when there is eye contact
– Discoloration of teeth and tongue
– Biocompatibility issues with dental materials

Benefits of Chlorhexidine
– Reduces the risk of hospital-acquired infections in intensive care unit patients
– Effective in reducing plaque and preventing dental caries
– Used as a preoperative mouthwash to reduce oral bacteria
– Provides antimicrobial activity against a wide range of microorganisms
– Used for wound management in veterinary medicine

Chemical Properties, History, and Research on Chlorhexidine
– Chemical formula: C22H30Cl2N10
– Molecular weight: 505.44 g/mol
– Soluble in water and alcohol
– Exhibits both bactericidal and bacteriostatic properties
– Forms complexes with bacterial cell membranes, disrupting their integrity
– First synthesized in the 1950s
– Initial studies focused on its antiplaque activity
– Extensive research on its antimicrobial properties and clinical applications
– Ongoing research to explore new formulations and uses of chlorhexidine
– Widely used and studied in various medical and dental fields

Merriam-Webster Online Dictionary
chlorhexidine (noun)
an antibacterial compound CHClN used as a local antiseptic (as in mouthwash) and disinfectant especially in the form of its hydrochloride or gluconate - 22 30 2 10
Chlorhexidine (Wikipedia)

Chlorhexidine is a disinfectant and antiseptic with the molecular formula C22H30Cl2N10, which is used for skin disinfection before surgery and to sterilize surgical instruments. It is also used for cleaning wounds, preventing dental plaque, treating yeast infections of the mouth, and to keep urinary catheters from blocking. It is used as a liquid or a powder. It is commonly used in salt form, either the gluconate or the acetate.

Chlorhexidine
Clinical data
Pronunciationklɔː(r)ˈhɛksɪdiːn
Trade namesBetasept, ChloraPrep, Chlorostat, others
Other namesCHX, CHG, 1,6-bis(4-chloro-phenylbiguanido)hexane
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • AU: A
Routes of
administration
Topical
ATC code
Legal status
Legal status
  • AU: S5, S6, S7
  • US: OTC / Rx-only
Identifiers
  • N,N1,6-Hexanediylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)]
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.217 Edit this at Wikidata
Chemical and physical data
FormulaC22H30Cl2N10
Molar mass505.45 g·mol−1
3D model (JSmol)
Melting point134 to 136 °C (273 to 277 °F)
Solubility in water0.8
  • Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1
  • InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34) checkY
  • Key:GHXZTYHSJHQHIJ-UHFFFAOYSA-N checkY
  (verify)

Side effects may include skin irritation, tooth discoloration, and allergic reactions, although the risk appears to be the same as other topical antiseptics. Chlorhexidine rinse is also known to have a bitter metallic aftertaste. Rinsing with water is not recommended as it is known to increase the bitterness. It may cause eye problems if direct contact occurs. Use in pregnancy appears to be safe. Chlorhexidine may come mixed in alcohol, water, or surfactant solution. It is effective against a range of microorganisms, but does not inactivate spores.

Chlorhexidine came into medical use in the 1950s. Chlorhexidine is available over the counter in the United States. It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 273rd most commonly prescribed medication in the United States, with more than 1 million prescriptions.

Chlorhexidine (Wiktionary)

English

Etymology

From chlor- +‎ hex- +‎ -idine.

Noun

chlorhexidine (uncountable)

  1. (pharmacology) A particular chemical antiseptic and bacteriostatic.

Derived terms

Translations

... Read More
EmbedSocial
linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram