Family Friendly & Specialty Dentists in London, UK
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Medical use
- Treatment of Lyme disease
- Treatment of chronic prostatitis
- Treatment of sinusitis
- Treatment of pelvic inflammatory disease
- Treatment of rickettsial infections
Antibacterial
- Effective against Moraxella catarrhalis
- Effective against Brucella melitensis
- Effective against Chlamydia pneumoniae
- Effective against Mycoplasma pneumoniae
- Some strains of Pseudomonas aeruginosa have developed resistance
Antimalarial
- Active against erythrocytic stages of Plasmodium falciparum
- Not active against gametocytes
- Used in the treatment of malaria
- Can be used as prophylaxis against malaria
- Targeting a plastid organelle, the apicoplast
Side effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Increased risk of sunburn
Commercial use and availability
- Patented in 1957
- Came into commercial use in 1967
- Included in the World Health Organization's List of Essential Medicines
- Available as a generic medicine
- 79th most commonly prescribed medication in the United States in 2020 with over 9 million prescriptions
