Family Friendly & Specialty Dentists in London, UK
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History and Evolution of Tooth Development
- Dental anthropology researches tooth development evolution
- Variations in teeth provide insights for genetic basis of odontogenesis
- Teeth originated from dermal structures called odontodes
- Phylogenetic changes in teeth are associated with functional adaptation
- Reduction of teeth number is connected with decrease in jaw size
Genetic Causes of Maxillary Lateral Incisor Agenesis
- Tooth agenesis is not completely understood
- Mutations in MSX1 and PAX9 genes are related to tooth agenesis
- MSX1 and PAX9 are necessary transcription factors for normal teeth formation
- Deletion of the MSX1 gene results in cleft palate and failure of tooth development
Endogamy as a Cause of Maxillary Lateral Incisor Agenesis
- Maxillary lateral incisor agenesis can be caused by endogamy
- High incidence of MLIA found in the population of Basta, southern Jordan
- MLIA in this population is believed to be due to close genetic relationships
- Endogamy refers to breeding from closely related individuals
- MLIA can be used to indicate inbreeding in a population
Applications of Maxillary Lateral Incisor Agenesis in Anthropology
- MLIA can be detected from partial skeletal remains, useful in anthropology
- Non-metric morphological traits are used to detect genetic relationships in historic populations
- Non-metric cranial and dental traits are tested on burial sites
- Identifying genetically related individuals is important for determining shared characteristics
- Traits examined include tooth crown and root variants, size, number, and position
Related Concepts and Further Reading
- Hypodontia is related to tooth agenesis
- References provided for further reading and research
