Signs and Symptoms of Orofacial Granulomatosis: - Persistent or recurrent enlargement of the lips, causing them to protrude - Midline fissuring of the lip (median cheilitis) or angular cheilitis (sores at the corner of the mouth) - Oral ulceration (mouth ulcers) which may be aphthous-like or chronic and deep - Full width gingivitis - Fissured tongue

Causes and Associations of Orofacial Granulomatosis: - Unknown cause - Non-caseating granulomatous inflammation - Disagreement on whether it represents an early form of Crohn's disease or sarcoidosis - Possible association with oral Crohn's disease - Suspected sources of antigens include metals and additives/preservatives in foods

Diagnosis of Orofacial Granulomatosis: - Usually diagnosed through tissue biopsy - Cannot reliably distinguish between OFG, Crohn's disease, or sarcoidosis - Other causes of granulomatous inflammation are ruled out

Classification of Orofacial Granulomatosis: - OFG could be classified as a type of cheilitis and a granulomatous condition

Treatment of Orofacial Granulomatosis: - Anti-tumor necrosis factor α drugs (e.g. infliximab) - Dietary restriction of suspected or proven antigens - Management may involve cinnamon or benzoate-free diets